||What is pTeroPure®?
pTeroPure®, also known as pterostilbene (pronounced tero-STILL-bean), is closely related to resveratrol. Although similar in structure, pterostilbene offers the following advantages over resveratrol:
- Superior bioavailability
- Significantly longer half-life
- Greater cellular uptake
- Greater oral absorption and metabolic stability
What makes pterostilbene unique from resveratrol?
Pterostilbene is more bioavailable than resveratrol.1, 2
. While structurally related to resveratrol, pterostilbene differs from resveratrol by having an additional molecular group that increases its affinity for fats. This structural difference results in improved bioavailability by reducing its susceptibility to first pass metabolism in the intestinal cells and liver.3
. In a comparative pharmacokinetic animal study of oral resveratrol vs. pterostilbene, pterostilbene was about 80% bioavailable as compared to just over 20% for resveratrol.1
Pterostilbene was also found to be more effective in enhancing cellular antioxidant capacity, when compared to resveratrol, in mice.4
Claims Supported by Science
- Promotes healthy cellular function with powerful antioxidant activities 5*
- Promotes cognitive function as demonstrated in animal models 6, 7*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
- Kapetanovic, I.M., et al., Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemother Pharmacol, 2011. 68(3): p. 593-601.
- Yeo, S.C., P.C. Ho, and H.S. Lin, Pharmacokinetics of pterostilbene in Sprague-Dawley rats: the impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability. Mol Nutr Food Res, 2013. 57(6): p. 1015-25.
- Kosuru, R., et al., Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence. Eur J Pharmacol, 2016. 789: p. 229-43.
- Chiou, Y.S., et al., Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. J Agric Food Chem, 2011. 59(6): p. 2725-33.
- McCormack, D. and D. McFadden, A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev, 2013. 2013: p. 575482.
- Poulose, S.M., et al., Effects of pterostilbene and resveratrol on brain and behavior. Neurochem Int, 2015. 89: p. 227-33.
- Chang, J., et al., Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer’s disease. Neurobiol Aging, 2012. 33(9): p. 2062-71.